Protease Inhibitors and Phosphatase Inhibitors
MilliporeSigma™ Calbiochem™ U0124
A useful negative control for MEK inhibitors U0125 and U0126.
MilliporeSigma™ Calbiochem™ Mevastatin, Sodium Salt
Carboxylate form of Mevastatin that is active in whole cells and in cell-free assays.
MilliporeSigma™ Calbiochem™ Conduritol B Epoxide
Conduritol B Epoxide, CAS 6090-95-5, is an irreversible Inhibitor of glucocerebrosidase in neurons. Also inhibits α-glucosidase activity in a variety of species.
MilliporeSigma™ Calbiochem™ APE1 Inhibitor III
The APE1 Inhibitor III controls the biological activity of APE1. This small molecule/inhibitor is primarily used for Cell Structure applications.
MilliporeSigma™ Calbiochem™ Dexamethasone
Most active and highly stable glucocorticoid.
MilliporeSigma™ Calbiochem™ Chlorpromazine, Hydrochloride
Inhibits calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase (IC50 = 17 μM).
MilliporeSigma™ Calbiochem™ Cdk/Crk Inhibitor
The Cdk/Crk Inhibitor, also referenced under CAS 784211-09-2, controls the biological activity of Cdk/Crk. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
MilliporeSigma™ Calbiochem™ miR-372/3 Inhibitor, Neomycin-S
A cell-permeable neomycin derived artificial nucleobase conjugate. Inhibits the production of oncogenic miRNAs 372 (IC50 = 2.4 μM) by binding to pre-miRNAs and interrupts processing by Dicer.
MilliporeSigma™ Calbiochem™ KN-93, Water-Soluble
This KN-93 is a water-soluble version of KN-93 that acts as a reversible and competitive inhibitor of CaM kinase II (Ki = 370 nM for rat brain).
MilliporeSigma™ Calbiochem™ Muscimol
Muscimol is a constituent and psychoactive ingredient of the mushroom Amanita muscaria, that acts as a potent agonist of GABAA receptors.
MilliporeSigma™ Calbiochem™ Pifithrin-α, p-Nitro, Cyclic
A cell-permeable p53 inhibitor that exhibits 10-fold higher potency and 50% longer half-life than Pifithrin-α.
MilliporeSigma™ Calbiochem™ Sertraline Hydrochloride
A very potent uptake inhibitor highly selective for serotonin (Ki
MilliporeSigma™ Calbiochem™ Granzyme B Substrate I, Colorimetric
Colorimetric substrate for the detection of granzyme B and caspase-8 activity.
MilliporeSigma™ Calbiochem™ SKP2 E3 Ligase Inhibitor III
A cell-permeable benzothiazolylchromenone compound that disrupts Skp2-Skp1 interaction via direct Skp2 affinity binding and selectively prevents Skp2-, but not Fbw7- or β-TrCP-, Skp1-Cullin-1-F-box (SFC) complex-mediated substrates ubiquitination, effectively preventing Skp2 substrates activation (Akt) and degradation (p21 & p27) with concomitant down-regulation of cellular Skp2 protein level (10 to 20μM in HEK293T & PC3 cultures)
MilliporeSigma™ Calbiochem™ Lovastatin
Lovastatin, CAS 75330-75-5, is an anti-hypercholesterolemic agent that inhibits the activity of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase.